Elsewhere Valencia came from behind to take a narrow 2-1 advantage against last season's beaten finalists Alaves.
Ruben Soriano put the visitors ahead in the 66th minute, but Goncalo Guedes equalized in the 73rd minute, although Alaves keeper, Sivero will think he should have done better.
Alaves were reduced to 10 men four minutes later when Adrian Dieguez was shown his second yellow card and Rodrigo Moreno scored the winner eight minutes later to leave the tie finely balanced for next week's return leg.
Atletico Madrid suffered a surprise 2-1 defeat at home to Sevilla. Diego Costa put Atletico ahead with 17 minutes remaining, but an error from Atletico keeper Miguel Angel Moya, saw him palm a cross that was going wide, into his own net with 10 minutes remaining and Joaquin Correa gave Sevilla a surprise win with just two minutes left on the clock.
It is the first time that Sevilla have won away to Atletico in 10 years and they are the first Spanish side to defeat Atletico in their new ground.
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