Wissam Ben Yedder gave Sevilla a lifeline with a near post header from a free kick five minutes after the break.
It was 3-2 on the hour after former Sevilla defender Alberto Moreno committed a needless penalty and Ben Yedder sent Karius the wrong way.
Escudero then saw the Liverpool keeper tip his shot onto the bar as Sevilla threw everything forward in an act of faith, turning the game into a thrilling end.
Both sides had chances to add to their tally but failed setting the stage for a dramatic finale in which Guido Pizarro scored from close range after Liverpool failed to deal with a corner to send the home fans wild with delight.
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