Elsewhere, Wolfsburg progressed into the next round after edging Hannover 1-0 on the sole goal of Felix Uduokhai in the Lower Saxony derby.
Stuttgart bounced back from one goal to edge second division side Kaiserslautern 3-1.
Ishak Belfodil's only goal of the match helped Werder Bremen to overpower Hoffenheim 1-0.
Three second-half goals from Freiburg cancelled out Dynamo Dresden' s opener to reap a 3-1 victory.
Heidenheim crushed Jahn Regensburg 5-2 and Nuremberg saw off resilient Osnabruck to progress into the last 16.
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