Lee's defeat means that Chen will have a more smooth path to the final in the second half, but the fifth seed played down the chance of winning his third successive world title.
"Of course I hope to win the title again, but first of all you need to do well in each match. Every match is not easy. You need to focus on the next match instead of the semifinal or the final matches."
Chen's next opponent is 33-year-old Sony Dwi Kuncoro of Indonesia, who defeated Milan Ludik of Czech Republic 21-16, 21-7.
Elsewhere, third seed Viktor Axelsen of Denmark fought back from one game down to oust Takuma Ueda of Japan 17-21, 21-6, 21-13 while China's 10th seed Tian Houwei beat Hans-Kristian Solberg Vittinghus of Denmark 21-14, 17-21, 21-16.
In the women's competitions, top seed Akane Yamaguchi, who received a bye in the first round, breezed past Denmark's Line Hojmark Kjaersfeldt. China's Chen Yufei, Chen Xiaoxin and Sun Yu, the fifth seed, reached the third round.
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