Felix, 31, clocked 48.7 seconds in the second lap to lead the US quartet to the title in the women's 4x400m relay. Of her 16 world medals, 11 have been gold, while nine in total were won as part of the US relay team and seven individually. She has also won nine Olympic medals including six golds.
Elsewhere, Kenya's Hellen Obiri upset defending champion Almaz Ayana to win 5,000m gold. Kenya also finsihed a one-two in the men's 1500m as Elijah Manangoi held off Timothy Cheruiyot.
Mutaz Barshim, Qatar's Olympic silver medallist, won the men's high jump gold with a jump of 2.35m. Russia's Danil Lysenko took silver ahead of Syria's Majd Eddin Ghazal in third.
Double Olympic champion Sandra Perkovic of Croatia claimed the women's discus gold medal with a throw of 70.31m.
South Africa's Caster Semenya, the Olympic champion, won easily the women's 800m in a personal best one minute 55.16 seconds, the fastest time in the world for nine years.
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