Real Sociedad could go top if other results go their way and they beat Levante in San Sebastian and all eyes will be on home midfielder Martin Odegaard who has been in excellent form this campaign.
Valencia will be without strikers Rodrigo Moreno (suspended) and Kevin Gameiro with a muscle injury, meaning that Maxi Lopez is set to start in their home game against Sevilla.
Valencia is looking to bounce back from a 3-1 defeat to Osasuna, while Sevilla impressed as they won 2-0 at home to Getafe at the weekend.
Athletic Club Bilbao needs to end a run of five games without a win in which they have scored just two goals when they entertain Espanyol on Wednesday night and coach Gaizka Garitano could make several changes to his side. Espanyol will travel after a morale-boosting first league win under coach Pablo Machin away to Levante at the weekend.
Drama looks to be assured in the Benito Villamarin stadium as third from bottom Betis entertain fourth from bottom Celta Vigo in a game where the stakes are high for both coaches. At the moment both Betis coach Joan Ferrer 'Rubi' and Celta's Fran Escriba are clinging on to their jobs, but the loser on Wednesday looks almost certain to be sacked.
Eibar is also at risk of falling into the bottom three unless they beat in-form Villarreal, who scored four past Alaves last Friday night.
Mallorca entertains Osasuna in a game between two sides who won promotion to the top-flight last season before Getafe entertain league leaders Granada in the last game of the week.
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