Arsenal never really looked like getting anything from the game and the defeat piles the pressure on coach Unai Emery who appealed for "calm" when speaking to the press after the final whistle.
Tammy Abraham scored his 10th Premier League goal of the season and Christian Pulisic continued with his excellent form by scoring his fifth goal in three games as Chelsea beat Crystal Palace 2-0 to claim their sixth successive Premier League win.
Sheffield United's impressive season continued and the newly-promoted side was still unbeaten away from home after James Baldock's 78th-minute goal gave them a 1-1 draw away to Tottenham.
The draw was no less than Sheffield United deserved as Tottenham produced another disappointing show, which head coach Mauricio Pochettino after the game asked for time to "rebuild" his squad.
A reprieved Son Heung-min put Spurs ahead and Sheffield was unlucky not to equalize earlier than Baldock's goal after John Lundstram saw a goal ruled out by VAR because his big tie was deemed to be offside.
Manchester United followed their midweek Europa League win with a 3-1 triumph at home to Brighton on Sunday.
Andres Pereira and an own goal from Davy Propper put United 2-0 up after just 19 minutes and although Lewis Dunk headed Brighton back into the game in the 64th minute, Marcos Rashford restored United's two-goal advantage just a minute later.
Wolves claimed the Midlands derby with a 2-1 win at home to Aston Villa thanks to goals from Ruben da Silva and Raul Jimenez before Trezeguet scored an injury-time consolation goal for the visitors.
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