Brandt would not be denied on the hour mark, as he slotted home from Sancho's pass to put Dortmund 2-1 ahead.
The latter stages of the game saw Slavia throw everything up front, while Dortmund's Julian Weigl received his marching orders for a second yellow card in the 77th minute, but the German side rode out the storm to win the game and secure their place in the Champions League knockout stages.
"We have all made this win possible," said a relieved Favre afterwards. "It was a see-saw match with chances on both sides but we wanted the win. However, Slavia is a strong team and they gave us a hard fight. Roman Burki staged an unbelievable performance today."
With the result, Borussia Dortmund finish Group F in second place with 10 points, behind group winners Barcelona (14 points) but ahead of Inter (7 points) and Slavia Prague (2 points).
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