Basel were still not done with the scoring, while Frankfurt failed to put up resistance in the closing period, as Frei made it 3-0 following the build-up work from Bua with five minutes remaining.
With the result, Basel will take a three-goal advantage into the second leg in Frankfurt next week.
Elsewhere, Shakhtar Donetsk upset hosts Wolfsburg 2-1 after Marcos Antonio's late winner smoothed the way for the win. Anthony Brooks levelled for the "Wolves" after half time but the visitors had the last laugh in the closing stages.
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