Catania handed Palermo a 4-0 thrashing in the Sicily derby, moving five points clear of the relegation zone.
A brilliant second-half performance saw the hosts record an impressive victory in one of their biggest games.
An own goal from Palermo defender Federico Balzaretti sent them on their way three minutes after half-time.
Three goals in the space of 16 minutes ensured a romp as Gonzalo Bergessio, Pablo Ledesma and Simone Pesce got on the scoresheet.
It was Palermo's sixth defeat in their last seven outings, all but ending their hopes of a spot in Europe.
Bari recorded just their fourth win of the season with a surprise 2-1 victory at Parma.
A 92nd-minute winner from substitute Honduran midfielder Edgar Alvarez put Bari within 11 points of safety.
The visitors had taken a lead through Alessandro Parisi in the 64th minute but Parma striker Amauri equalised 10 minutes from time.
Alvarez provided the winner to give Bari their first win since being 1-0 victors at Lecce on January 7.
Cagliari ended a three-game winless run with a 1-0 victory over Genoa.
A goal from Robert Acquafresca in the 16th minute was enough to send Cagliari into 10th spot and leave Genoa in mid-table.
Cesena scored a late equalizer to secure a 2-2 draw against Fiorentina.
Luis Jimenez gave Cesena an unlikely early lead but Alberto Gilardino ensured his side would go into the break on level terms.
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