Barcelona looked comfortable, but failed to create further chances and Osasuna almost made them pay in the closing minutes of the first half when Crisitan Vadocz headed at Victor Valdes.
Valdes then had to react well to tip a shot from former Barca youngster Damia Perez onto the woodwork and out to safety.
Guardiola reacted by bringing Andres Iniesta on at halftime for Jeffren, who looked to have suffered a muscle injury and before the hour Leo Messi replaced Villa, who was cheered off the pitch.
Shortly afterwards Barca were forced into their final change of the game when Xavi Hernandez replaced the injured Gabi Milito. The second half was turning into a tedious affair with neither side able to move the ball fluidly, although the play was mainly in the Osasuna half and it was not until the 74th minute that Iniesta managed Barca's first decent shot of the half with an effort that flew over the Osasuna bar.
Messi scored Barcelona's second goal with three minutes remaining, but it was not a good performance from the league leaders.
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