research is highlighted in this months Archives of Internal Medicine with a call for doctors who care for heart patients to start rigorously checking out the kidneys, and for better care of early kidney disease. 7
The link sounds logical. After alla , high blood pressure and diabetes are chief risk factors for both chronic kidney disease and heart attacks. But the link goes beyond those risk factors, stresses McCullough: Once the kidneys begin to fail, something in turn10 accelerates heart disease, not just in the obviously sick or very old, but at what he calls a shockingly early age. McCullough and colleagues tracked more than 37,000 relatively young peopleaverage age 53 who volunteered for a kidney screening. Three markers of kidney function were checked: The rate at which kidneys filter blood, called the GFR or glomerular filtration rate11; levels of the protein albumin in the urinei and if they were anemic. They also were asked about previously diagnosed heart disease.
The odds of having heart disease rose steadily as each of the kidney markers worsened. More striking was the death data. At this age, few deaths are expected, and indeed just 191 people died during the study period. But those who had both CKD and known heart disease had a threefold increased risk of death in a mere 2 1/2 years, mostly from heart problems. This study is very much a wake-up call, McCullough says.
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