他们在这一工作中是按癌症基因组协作组的标准程序操作的,
The novelty of their approach was that the women in question had each been involved inone of two clinical trials of a drug called letrozole.
但其方法的新颖之处是,他们还同时进行一种名为来曲唑的药物的临床试验。该试验有两种,每个病人都接受其中的一种。
These trials established letrozole as a standard treatment for people with this type of breastcancer,
这些试验证实来曲唑是这类乳腺癌的标准治疗方法,
but not all patients benefit equally from the drug.
但它对每个病人的疗效并不一样。
Dr Ellis hoped to find out why.
埃利斯博士希望找出其原因。
As they report in Nature, he and his team discovered 18 genes that were often mutated.
正如他们在《自然》杂志中所报告的那样,埃利斯和他的团队发现了18种经常发生突变的基因,
Some were the usual suspects of cancer genetics.
其中有些是癌症遗传学通常怀疑的对象。
These included p53, a gene that, when working properly, suppresses cancer by regulatingDNA repair, cell division and cellular suicide,
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