He thought he might be able to change that, on the basis of work he had carried outpreviously, trying to design a vaccine against nicotine. In particular, nicotine is a highlyflexible molecule.
他认为他可以设法改变这一现状。就目前的研发成果的基础上,他正在研发某种对抗尼古丁的疫苗。
That makes it hard for the immune system to recognise.
尤其是,尼古丁是一种较灵活的分子,使免疫系统更加难以识别。
To overcome this, his team on the nicotine project had to work out how to fix their haptensto the carrier protein in a way that rendered them less capable of twisting and turning, andthus made them easier for the immune system to identify.
为克服这一困难, Janda博士的团队已经研究出如何令半抗原附在蛋白质载体上,并让其活动稳定一些。如此,免疫系统便能更好的识别出病毒。
In the new study, Dr Janda and his colleagues report that they have performed a similar trickwith methamphetamine haptens.
Janda博士和他的同事们最新研究表示,他们已成功应对甲基苯丙胺半抗原,
They used computer models to visualise the haptens in three dimensions and thus work outhow the molecules could be rearranged such that they could not spring, twist or turn whenbeing examined by the immune system.
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