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Whip hand?

These are features that can be seen today in the writing and speech of patients experiencing the manic phase of psychiatric illnesses such as bipolar disorder.

Mania, or harmful euphoria, is at one end of a spectrum of mood disorders, with sadness, or depression, at the other. George’s being in a manic state would also match contemporary descriptions of his illness by witnesses.

They spoke of his “incessant loquacity” and his habit of talking until the foam ran out of his mouth. Sometimes he suffered from convulsions, and his pages had to sit on him to keep him safe on the floor.

The researchers have even thrown doubt on one of the key planks in the case for porphyria, the blue urine. George III’s medical records show that the king was given medicine based on gentian. This plant, with its deep blue flowers, is still used today as a mild tonic, but may turn the urine blue.

So maybe it wasn’t the king’s “madness” that caused his most famous symptom. It could have simply been his medicine. ...

George III’s recurring bouts of illness caused him to withdraw from daily business to recuperate out of the public eye at secluded Kew Palace, near Richmond.

Each time he withdrew to Kew, this triggered a crisis - who was to make decisions in his absence?

His son, the Prince of Wales, with whom George III had a terrible relationship, wanted to be appointed regent, and to act as the king in everything but name. But the future George IV was very much associated with the political opposition, and the government was determined to keep him out.