“研究表明端粒是衰老和疾病风险的一个指标,但这些纵向研究结果提出了端粒长度可以作为一种生物标志物来跟踪压力的影响的可能性,”研究小组成员之一、密歇根大学(University of Michigan)的神经学家和精神病学家斯里扬·森(Srijan Sen)说。
"It will be important to study how telomere changes play out in larger groups of medical trainees and in other groups of people subjected to specific prolonged stresses."
“研究端粒变化如何在更大范围的医学培训生群体和其他长期承受特定压力的人群中发挥作用,将是很重要的。”
The researchers took DNA samples from 250 new doctors at the start and end of their first intern year. These were compared to samples from 84 U-M freshmen students. In addition, the team measured the participants' mental well-being and stress levels over time with the use of questionnaires throughout the year.
研究人员从250名新医生身上提取了DNA样本,这些医生都是在他们第一个实习年度的开始和结束时进行的。这些数据与84名密歇根大学新生的样本进行了比较。此外,研究小组还通过全年的问卷调查,测量了参与者的心理健康和压力水平。
Besides "telomere attrition" being six times greater in the doctors, some other interesting findings came to light – for example, the longer hours the new doctors worked, the faster their telomeres shrank.
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