But because patients in the study received twice-daily pills that circulated ruxolitinib throughout their bodies, rather than topical cream, he said they were “treated systemically with a very toxic drug” that can cause liver and blood problems, infections and other ailments.
但由于参与这项研究的患者每天两次服用鲁索利替尼片剂——而不是涂抹膏剂——药物成分会在整个身体内循环,他认为他们在接受以毒性很强的药物为手段的全身性治疗,该药物有可能让肝脏和血液出问题,还有可能引发感染以及其他疾病。
Although the patients have experienced few side effects, the study is small and not a randomized trial comparing ruxolitinib to other treatments.
尽管患者几乎还没感受到什么副作用,但这项研究规模很小,也并非一次拿鲁索利替尼和其他治疗手段作对比的随机试验。
If ruxolitinib could be applied topically, Dr. Cotsarelis said, “this would be an amazing breakthrough.” Until then, “patients are going to rush in demanding this treatment, and I would not give it.”
柯萨莱利斯博士说,假如可以局部应用鲁索利替尼,“那将是惊人的突破”。在此之前,“要求用该疗法治疗的患者未免显得草率,我是不会给他们开处方的”。
Dr. Raphael Clynes, a co-leader of the research while he was a Columbia professor (he now works for Bristol-Myers Squibb), said the team tested cream and pills on mice, and planned to test a cream on people.
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