Atletico Madrid get the ball rolling on the round of games when they travel to face a Villarreal side that has slipped badly with a run of four defeats and a draw from their last five games.
Neither side can afford to lose in the Estadio de la Ceramica, although anything but a win for Atletico would just about end their title hopes.
Granada has also lost four games from the last five as they prepare to face Alaves, who have strikers Joselu and Lucas Perez in fine form.
Saturday also sees a Valencia city derby as Valencia makes the short trip to face Levante in the Ciudad de Valencia Stadium where Levante has beaten Mallorca and Barca in their last home games.
Eibar entertain Getafe on Sunday lunchtime needing to end a run of results which have taken them to just above the relegation zone.
Meanwhile, the Benito Villamarin Stadium sees a duel between two in-form sides as Betis look to stretch their winning run to three matches against Athletic Club Bilbao, who are looking for win number four, but who will be without the suspended Raul Garcia.
Fourth place Real Sociedad have a difficult trip to play Valladolid but have strikers Willian Jose, Mikel Oyarzabal and Martin Odegaard in fine form.
Expect drama in Butarque as the bottom of the table Leganes entertain third-bottom Celta Vigo. Both sides have improved since changing coaches, but need to start turning improved displays into wins or run the risk of being cut further adrift in the battle for survival.
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2020-09-15
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