但如果修复不起作用,则这些信号就不会停止。
The swelling causes pain, and the patient suffers.
肿痛造成痛苦,而病人只能忍受。
But macrophage signalling also involves SNAP-25, so Dr Chapman thinks he can usebotulinum toxin to shut the cells up.
但是巨噬细胞的信号通路中也包括SNAP-25,因此查普曼博士想,他能够用肉毒素来关闭这些免疫细胞。
The problem is that macrophages have no synaptotagmin on their surfaces.
问题在于,巨噬细胞的表面并没有SYT蛋白,
They do, though, have other proteins, called Fc receptors.
他们表面有的是另外一种被称为Fc受体的蛋白。
What is needed is a way to get toxin molecules to attach themselves to Fc receptors.
现在只需要找到一个办法,让肉毒素结合到Fc受体上去,
And this is what Dr Chapman thinks he has managed.
而查普曼博士认为,他办到了这一点。
His trick is to link each molecule to an antibody.
他的绝招是将每个分子与抗体连接起来。
An antibody is a protein that binds to a hostile invading organism.
抗体是一种能结合入侵有机体的分子,
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