来自荷兰癌症研究所的勒内.伯纳兹博士便是其中一位。9月18日,他在旧金山一个由美国癌症研究协会组织的研讨会上宣布,发现了使癌细胞恢复对Xalkori敏感性的方法。然而比这更具意义的是,此种方法的原理,同样适用于打破其他多种由于产生抗药性而导致其疗效减退的抗癌药物所遭遇的瓶颈。
One of the problems with cancer is that the mutations which cause it are often hidden in aplethora of others that have no direct bearing on the disease. Normal DNA sequencing cannotdistinguish which mutations are important and which are not. Dr Bernards, however, thinks hecan, by using molecules called short hairpin RNAs.
攻克癌症的困难之一,是致癌突变通常都隐藏在其他众多非致癌突变之中,而正规的DNA测序不能检测区别出两者的不同。不过现在,伯纳兹博士称,利用一种叫做短发夹RNA的分子,他找到了区别二者的方法。
On the pin money
深入探究
RNA is a molecule similar to DNA, except that its molecules are usually much smaller. One ofits jobs is to act as a messenger carrying genetic information from a cells nucleus to themachinery which makes proteins. Each messenger is an edited copy of one strand of the DNAdouble helix. Double-stranded RNA does exist, but mostly in viruses. Mammalian cells make onlythe single-stranded variety. If a cells defence mechanisms detect double-stranded RNA theydestroy it, to protect against infection.
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