Steven Cole of the University of California, Los Angeles, thinks he may know why this is so. He told the AAAS meeting in Washington, DC, about his work studying the expression of genes in lonely people. Dr Cole harvested samples of white blood cells from both lonely and gregariouspeople. He then analysed the activity of their genes, as measured by the production of asubstance called messenger RNA. This molecule carries instructions from the genes telling acel which proteins to make. The level of messenger RNA from most genes was the same in both types of people. There were several dozen genes, however, that were less active in the lonely, and several dozen others that were more active. Moreover, both the less active and the more active gene types came from a small number of functional groups.
加州大学洛杉矶分校的Steven Cole认为他可能知道这是为什么。他在华盛顿特区举办的美国科学促进会大会上展示了他对孤独的人的基因表达所做的研究。Cole博士收集了孤独之人和爱交际之人的白细胞样品。然后他分析了他们基因的活性靠测量信使RNA的多少。这种分子携带着基因上的指令,告诉细胞合成那类蛋白质。在这两种人中,大多数基因的信使RNA的水平是一样的。然而有些基因在孤独之人中活力较弱,同时另外一些基因却活力较高。而且,无论是活力较高的基因还是活力较低的基因都来自少数功能群。
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