What Dr Cole seems to have revealed, then, is a mechanism by which the environment reaches inside a persons body and tweaks its genome so that it responds appropriately. It is not that the lonely and the gregarious are genetically different from each other. Rather, their genes are regulated differently, according to how sociable an individual is. Dr Cole thinks this regulation is part of a wider mechanism that tunes individuals to the circumstances they find themselves in. Where it goes wrong is when loneliness becomeschronic, and the inflammatory response becomes chronic a the same time.
Cole博士想要揭示的是这样一种机制:环境可以影响人们体内的生化活动,调整人体内的基因组以让其做出合适的反应。并不是说孤独之人和爱交际之人在基因上彼此不同。而是他们根据个人对交际喜爱的程度不同,各自以不同的方式调控各自的基因。Cole博士认为这种调节是一种更广泛的让个人适应他们所在环境的机制中的一部分。当孤独的生活状态变成一种常态,问题就出现了炎症反应同时也变成常态了。
Before civilisation intervened, such chronic loneliness would have been s rare that evolution would have ignored it. Now,paradoxically, the large population that civilisation makes possible means loneliness iscommonplaceand with it consequences that natural selection, which is blind to the future, has not yet had time to deal with.
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