Anyways as an adverb, "in and of itself/themselves" is similar to itself/themselves (for emphasis), or intrinsically (talking about things' inherent nature and qualities), or per se (Latin for in itself, by itself).
And here are two examples of "in and of itself/themselves" to help deepen the impression.
1. Vision loss linked to greater risk of early death (Reuters, September 9, 2007):
Older men and women with cataracts or age-related macular degeneration (ARMD) are at increased risk for suffering an early death, relative to older people without these two types of visual impairment, a study hints.
But it's not clear, the study team notes, whether the vision loss is simply a marker for deterioration due to aging or if, in and of itself, the conditions boost mortality risk.
2. New York Times Puts Reader Comments on Main Page - Good Idea? (www.readwriteweb.com, October 12, 2007):
Silicon Alley Insider spotted the New York Times web site displaying reader comments prominently under the top story on their front page today. The comments in-and-of themselves are not newsworthy – they came from a post on the site's news blog and the Times has linked to comment threads on the main page before. But this is, to anyone's recollection, the first time the site has actually displayed the actual comments themselves on the site.
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