Carney said Washington has "no evidence to substantiate the charge that the opposition has used chemical weapons," urging instead the Syrian government to refrain from using the weapons of mass destruction and secure them from radical Islamists or face "consequences."

Israel has threatened military strikes should Syria's chemical weapons fall into the hands of Hezbollah, a Shiite militant group in Lebanon allied with Iran and Syria.

During his trip to Israel, Obama is expected to try to smooth over his relations with Prime Minister Benjamin Netanyahu strained over the years by their disagreements over settlement building on the occupied land and how best to stop Iran from obtaining a nuclear bomb.

Kerry arrived in Israel on Tuesday in preparation for Obama's visit.

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