Having won Wednesday night in the Commons, where a string of amendments were defeated, it almost guarantees that May will be on course to tell Brussels within weeks to start the EU exit process.
May's government only introduced the briefly worded bill into parliament last week, determined to see it fast-tracked through the parliamentary process.
It has meant members of parliament (MPs) sitting until midnight on some occasions to complete a series of debates.
Attempts by the Scottish Nationalist Party (SNP) to ensure the Scottish Parliament in Edinburgh could have a vote on Brexit, as well as a call by the minority Liberal Democrats for a second national referendum, each failed, as did a string of proposed amendments by the main opposition Labor party.
In the final vote, the result indicated that some Labor MPs had defied an instruction from their leader Jeremy Corbyn to vote in favor of the Article 50 bill.
A number of his shadow cabinet members have already resigned, and more may quit as a result of the vote.
Before the result was even announced it was reported that Labor's shadow business secretary Clive Lewis resigned from Corbyn's shadow cabinet, saying he could not vote in favor of the Brexit bill.
Under parliamentary convention in Britain a minister or shadow minister disobeying the leadership is expected to resign or be fired. The vote will add to the ongoing civil war within the Labor Party that erupted after Corbyn's election as leader.
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