"But it is not as well-known that each time a normal cell divides and copies its DNA to produce two new cells, it makes multiple mistakes.

“但是，很多人不知道的是，每当一个正常的细胞分裂并复制DNA从而产生两个新细胞时，会发生各种各样的错误。”

"These copying mistakes are a potent source of cancer mutations that historically have been scientifically undervalued, and this new work provides the first estimate of the fraction of mutations caused by these mistakes."

“这些细胞分裂时产生的错误是导致癌基因变异的重要原因，但是，一直以来，这种观点在科学领域都未受到足够重视。这是第一次有研究猜测认为，癌基因的变异可能源于细胞分裂时产生的错误。”

The research, published in the journal Science, indicates that almost two-thirds of cancer-causing mutations are due to DNA copying errors.

这项发表在《科学》期刊上的研究表明，将近三分之二的致癌基因突变可能源于DNA复制时产生的错误。

The discovery helps explain why cancer often strikes people who follow all the rules of healthy living and have no family history of the disease.

这一发现有助于解释为何罹癌的通常是那些生活方式健康且无家族病史的人。

Cancers triggered by copying errors could occur "no matter how perfect the environment", according to co-author Dr Bert Vogelstein, also from the Johns Hopkins Kimmel Cancer Center.

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