“高风险成神经细胞瘤对传统治疗方法会表现出抗性,病人存活几率也很低”,来自中弗罗里达大学的主要研究员,塔玛拉J·西莫兰德说道。
Using curcumin to fight cancer isn't a new idea, but it's difficult to get the chemical into drugs because of its low solubility and poor stability. Nanoparticles could fix that.
利用姜黄色素来抗癌并不是什么新想法,但由于它溶解度和稳定性都很低,因此制成药物十分困难。纳米颗粒倒是可以解决这个难题。
Even better, the nanoparticles were more effective against the type of cells usually most resistant to conventional drugs.
更值得庆幸的是,纳米颗粒在对抗那些对传统药物显示出抗性的细胞尤为有效。
As neuroblastoma is usually very difficult to treat, that's a promising start for these spicy nanoparticles. Not only is it largely resistant to anti-cancer drugs, it's also known to cause health problems after successful treatment, including hearing loss and other disabilities. It also often returns after treatment.
成神经细胞瘤很难治疗,对这些辣味纳米颗粒来说,目前进展初期还是有很大希望的。因为成神经细胞瘤不仅对大多数抗癌药物都有抗性,而且治疗成功后仍旧会造成健康问题,包括听力受损和其它残疾症状,而且可能会复发。
If we can develop an effective nanoparticle approach to fighting neuroblastoma, it would be yet more evidence of the potential of treating disease at the smallest possible scales: nanoparticles have previously been shown to help kickstart the human immune system to help fight cancer, for example.
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