He said: "We can only imagine what the next century will bring. Thank you for saving my life."
The Academy Award winners were married in 2000 and have two children, a son, Dylan, 12, and daughter Carys, 11.
Zeta-Jones underwent treatment for bipolar disorder while Douglas was recovering from his treatment, and they separated for several months last year.
She was apparently upset at his candid disclosure during interviews that he contracted his cancer from oral sex, without making it clear that he got HPV, the virus that leads to the disease, before they met.
They have since reconciled and Zeta-Jones has moved back into their New York apartment.
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