但这还不足以消灭病人体内的艾滋病毒。研究人员说,移植后,只有大约5%到8%的患者骨髓细胞携带这种经过编辑的基因。邓宏魁说,“在未来,进一步提高基因编辑的效率和优化移植程序等措施应该会加速向临床应用的转变。”
But he doesn't see this as a setback."The main purpose of the study was to evaluate the safety and feasibility of genetically-edited stem cell transplantation for AIDS treatment," said Deng.
但他不认为这个治疗是一次失败。“这项研究的主要目的是评估基因编辑干细胞移植治疗艾滋病的安全性和可行性,”邓宏魁说。
According to Deng, this was a success: the scientists didn't detect any gene editing-related adverse events, even if "more long-term in-depth studies are needed for off-target effects and other safety assessments," Deng said.
他认为这个试验很成功:科学家们没有发现任何与基因编辑相关的不良事件,邓宏魁说,即使“需要更长期深入的研究来进行脱靶效应和其他安全评估。”
The CCR5 gene mutation has been associated with a 21% increased risk of dying early, according to a paper published in Nature in June, though it's unclear why.
《自然》杂志今年6月发表的一篇论文称,CCR5基因突变与早逝风险增加21%有关,不过原因尚不清楚。
The team that conducted the study had previously transplanted edited CCR5 human cells into mice, making them resistant to HIV. American scientists have carried out similar experiments on humans, with some success, using an older gene editing tool called zinc finger nuclease.
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