The Syrian Observatory for Human Rights said as many as 3,000 airstrikes and artillery shelling targeted Eastern Ghouta over the past four days.

The UK-based watchdog group said a total of 310 people have been killed and over 1,550 others wounded by the shelling on Eastern Ghouta over the past few days.

The oppositional monitor said six medical centers and hospitals have gone out of service as a result.

Also, the International Committee of the Red Cross (ICRC) has called for restraint and access to the wounded after "the deadly escalation of fighting that has hit Damascus in recent days."

"The fighting appears likely to cause much more suffering in the days and weeks ahead, and our teams need to be allowed to enter Eastern Ghouta to aid the wounded," said Marianne Gasser, ICRC's head of delegation in Syria, in a statement released on Wednesday.

The statement said the medical personnel in Eastern Ghouta can't cope with the high number of injuries, adding that the area does not have enough medicines and supplies, especially after medical facilities were reported to have been hit.

"Wounded victims are dying only because they cannot be treated in time. In some areas of Ghouta, entire families have no safe place to go," Gasser said, adding that "on the other side of the frontline, people in Damascus are in constant fear that their children will be hit by falling mortars. This is madness and it has to stop. Civilians must not be targeted."

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