They are then fused together with proteins derived from strains of E. coli bacteria, Science Alert reports.
根据《科学前沿》的报道,科学家将这种蛋白质与大肠杆菌菌株中提取的蛋白质混合。
Previous studies had shown this combination to be effective in protecting against cavities, but produced unwanted side effects.
此前研究表明,这种混合物对预防龋齿有效,但会产生有害的副作用。
工作原理
The new vaccine is fused together with a third protein, derived from flagella proteins - cells that help the combination to move around.
科学家在这种新的疫苗中添加了另外一种蛋白质——提取自鞭毛素蛋白,帮助疫苗起效。
The prototype vaccine, which produced fewer side effects, was administered as a nasal spray in laboratory tests on rodents.
疫苗样品产生的副作用较少,以鼻部喷雾的方式对啮齿动物进行了实验测试。
Writing in the journal Scientific Reports, the researchers found it offered a similar amount of the protection as the initial vaccine.
研究人员发现,与初始疫苗相比,重组后的疫苗提供的保护效应大致相当。研究报告发表在《科学报告》期刊上。
The vaccine had a 64.2 percent prophylactic efficacy. It also reversed tooth decay by 53.9 percent, the researchers noted.
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