华盛顿大学医学院的米兰•切赫达说:“我们想尽一切办法治疗病人,最后却发现病人的肿瘤几个月后就复发了,这真令人沮丧。”
"We wondered whether nature could provide a weapon to target the cells most likely responsible for this return."
“我们想知道大自然能否给我们一种武器,来对付最可能导致这种复发的细胞。”
The secret to Zika's apparent success, the latest experiments show, is that the virus specifically takes aim at brain cancer stem cells, the kind that tend to survive chemotherapy and spread.
最新研究表明,寨卡病毒实验取得明显成功的秘密在于,这种病毒会专门攻击脑癌干细胞。这种细胞往往能够在化疗中生存下来并继续扩散。
When a pregnant woman is infected with Zika, she faces a higher risk of bearing an infant with an unusually small head because Zika destroys these cells, leading to the irreversible condition known as microcephaly.
如果孕妇感染寨卡病毒,婴儿患小头症的风险会更高,因为寨卡病毒会破坏这些细胞,造成被称为小头畸形的不可逆损害。
Zika tends to attack neuroprogenitor cells, which are common in fetuses but rare in adults.
寨卡病毒倾向于攻击神经前体细胞,这种细胞在胎儿体内很常见,但在成人体内数量很少。
"We showed that Zika virus can kill the kind of glioblastoma cells that tend to be resistant to current treatments and lead to death," said study co-author Michael Diamond, a professor of medicine.
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