For this reason, those in the capital city need to be "especially cautious," he said.
The government recognises that the "very draconian" measures he has outlined will be "asking a lot" from the everyone, added Johnson, who was the former London mayor.
London is at the center of the escalating coronavirus outbreak in Britain, according to the latest official figures.
Hospitals in the capital are braced for a wave of cases within weeks as a sharp rise in the number of deaths -- to 53 by Monday in Britain according to Health Secretary Matt Hancock -- suggested it is a fast-developing situation.
All of the top 12 areas with the highest number of COVID-19 cases are in the capital or in commuter-belt counties, according to official figures.
As of Sunday, out of 1,099 confirmed cases in England, 407 were in the London NHS region.
With the capital being hardest hit, Mayor Sadiq Khan also appealed to Londoners to look after the elderly and people with underlying health conditions who are most in danger.
"Our priority must always be to look out for the older and more vulnerable people in our communities who may be most at risk," the mayor said ahead of a visit to Croydon to reassure Londoners about the capital's response to COVID-19.
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