Karlsruher secured their first win since Oct. 3, ending a nine-game winless streak in coach Edmund Becker's 50th Bundesliga match.
Bremen are now winless in five away games and missed out on a confidence boost ahead of their last Champions League game against Inter Milan on Tuesday.
For new Stuttgart coach Markus Babbel, a 3-0 win at Cottbus saw his second victory in two Bundesliga matches.
Goals from Roberto Hilbert, Jan Simak and Sami Khedira secured Stuttgart's first away win since Matchday 1.
Cottbus haven't won against VfB in eight matches and since 2000,and captain Timo Rost picked up his fifth booking and will miss the next match at Bayer Leverkusen.
On Saturday, Bochum's winless run was extended to twelve matches with a 4-0 defeat at Eintracht Frankfurt. Bochum also lost goalkeeper Daniel Fernandes, who was sent off for a professional foul after just five minutes.
The only draw on Saturday is the clash between Bielefeld and Dortmund, the match ended goalless.
On Sunday, Wolfsburg will travel to Hannover while Hamburg will face the challenge of Koeln at home.
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