同样来自美国约翰霍普金斯大学金墨尔癌症中心的伯特•沃格斯坦博士是本次研究论文的共同著者,他表示,“不管外部环境多么无可挑剔”,由基因复制错误导致的癌症都有可能发生。
He said: "We need to continue to encourage people to avoid environmental agents and lifestyles that increase their risk of developing cancer mutations.
他还提到:“我们要继续鼓励人们避开那些增加癌基因变异风险的环境因素和生活方式。”
"However, many people will still develop cancers due to these random DNA copying errors, and better methods to detect all cancers earlier, while they are still curable, are urgently needed."
“不过,很多人仍会因为DNA复制时随机产生的错误患上癌症,因此,我们现在急需找到更好的方法及早检测出所有癌症,在它们还可以治愈时发现它们。”
The team studied mutations that drive abnormal cell growth in 32 different types of cancer.
研究人员对32种癌症中导致细胞异常生长的变异原因进行了研究。
Using DNA sequencing and epidemiological data, they developed a mathematical system of assessing the role of genetic copying errors in cancer.
研究人员利用DNA测序和流行病学资料,建立了数学模型,以此评估基因复制时随机产生的错误在罹癌中起到的作用。
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