像布洛芬这样的非类固醇抗炎镇痛药对某些偏头痛患者有效。但是上世纪90年代面市的曲坦类偏头痛药对很多患者来说仍然是最好或唯一的药物选择。然而,大约一半的患者要么服用这类药后没有效果,要么由于其他健康原因不能服用此类药物。
CGRP, which stands for calcitonin gene-related peptide neurotransmitter, has long been thought to play a role in migraines, but for much of that time for the wrong reason. Part of the confusion was because of a misunderstanding of migraines themselves.
CGRP是降钙素基因相关口神经递质的缩写,长久以来它被认为在偏头痛中发挥了作用,不过很长一段时间里这种看法的依据都是错误的。出现混乱的原因是对偏头痛本身产生了误解。
Why they occur still isn't clear, but specialists say they have recently begun to understand the migraine as a brain disorder and not a vascular disorder. Until about 12 years ago, they were believed to stem from constriction of blood vessels in the brain. The dilation of the vessels to compensate then led to the throbbing pain, so the thinking went.
偏头痛发生的原因尚不清楚,但是专家们说他们最近开始把偏头痛当作一种大脑病症而非血管病症。直到大约12年前,偏头痛都被认为是由于大脑血管收缩引起的。血管的补偿性扩张就导致了搏动痛,当时的人们就是这么想的。
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