Spall, one of Leigh's regular collaborators, said he was ideally cast as Turner because "he was a funny-looking, fat little man and so am I".
"Genius is not always in the most romantic of packages," the actor continued. "Most geniuses are strange and are often odd-looking sociopaths."
He said Turner was "slightly brutish - a man with love in his heart but not sure where to put it".
In addition to his paintings, the film deals with Turner's personal life and his relationships with women - among them his housekeeper, a Margate widow and two daughters he declines to acknowledge.
The Guardian's Peter Bradshaw said Mr Turner - one of 18 titles in contention for this year's Palme d'Or award - represented "another triumph"for Leigh and Spall.
"Every scene... is expertly managed; every comic line and funny moment adroitly presented and every performance given with intelligence and love," he said in his five-star review.
In his own five-star rave, The Telegraph's Robbie Collin said Spall "gives what's probably the finest performance in his career".
Spall, 57, also drew praisefrom Screen International's Jonathan Romney, who said he was "magnificent" in a film that "may be the most entertaining art biopic yet made".
The premiere of Leigh's film coincides with the issue of a set of Royal Mail stamps in which Secrets and Lies features alongside nine other British titles.
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