Other than his film work, he has embraced human rights causes such as the Darfur crisis in Sudan.
Lebanese-born British lawyer Amal Alamuddin has defended Julian Assange of Wikileaks and former Ukrainian Prime Minister Yulia Tymoshenko among others.
She met Clooney through her work.
People in her native village in Lebanon, Baakline in the Chouf district, welcomed news of her impending marriage, AP reports.
"We congratulate them and we hope that the happiness will be international," said shopkeeper Ghassan Bou Hatoum.
The couple's choice of Venice for the wedding is apt as Clooney is a frequent visitor to its film festival. He also owns a villa on Lake Como, north of Milan.
Despite the long build-up to the wedding, interest still abounded on social media at news of the knot being tied.
"George Clooney is married," wrote one tweeter. "Heterosexual men of earth release a collective sigh of relief. Everyone else mourns."
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