At least 43 civilians, mostly children, were killed on Thursday when Saudi-led coalition air strikes hit buses in Yemen's northern province of Saada.
The Saudi-led coalition later defended the airstrike as "legitimate" response to a deadly Houthi attack on the Saudi border city Jazan.
Houthi spokesman Mohammed Abdulsalam mocked the statement, saying "this is a war crime."
Henrietta Fore, head of the United Nations Children's Fund (UNICEF), strongly condemned the airstrike.
"Attacks on children are absolutely unacceptable," said Fore. "I'm horrified by the reported airstrike on innocent children, some with UNICEF backpacks. Enough is enough."
"Attacking children is the lowest any party of this conflict can go," UNICEF Yemen Resident Representative Meritxell Relano told UN News. "There is no justification whatsoever to attacking children."
The Saada attack was the latest in a series of recent airstrikes against civilians launched by the Saudi-led coalition on Yemen.
Last week, the Saudi-led coalition airstrikes struck the gate of al-Thawra hospital and adjacent fish market in Yemen's Red Sea port city of Hodeidah, killing 52 civilians and wounding 102 others.
Saudi Arabia has led an Arab military coalition that had intervened in the Yemen war since 2017 to support the government of exiled President Abd-Rabbu Mansour Hadi.
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