However, after Eibar had pegged Madrid back in their own half for much of the opening 45 minutes Ronaldo took advantage of a defensive error and a pass from Luka Modric to open the scoring.
Ivan Ramis equalized five minutes into the second half with a powerful header, but another error allowed Dani Carvajal to cross from Ronaldo to score the decisive goal 6 minutes from time.
Valencia all but assured Champions League football next season thanks to two goals from Rodrigo Moreno, who now has 12 this season.
The win gives Valencia an 11 point cushion over fifth-placed Sevilla, while Sevilla's season now hangs on the result of Tuesday's trip to Old Trafford.
Villarreal remain sixth after a 2-0 win away to Las Palmas thanks to second half goals from Carlos Bacca and Nicola Sansone, a result which leaves Las Palmas adrift in the relegation zone.
Raul Garcia scored twice as Athletic Club enjoyed a relatively easy 2-0 win at home to Leganes to end any lingering relegation fears.
Meanwhile Espanyol scored two second half goals through Leo Baptistao and Gerard Moreno to cancel out Willian Jose's first half opener for Real Sociedad who continue to make too many defensive errors.
Finally, Coke's 79th minute header gave Levante their first win in 16 games as they won 1-0 away to Getafe to give Paco Lopez a win on his debut as coach.
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