科学家发现当一种叫做CXXC5的蛋白质与散乱蛋白结合时,它们会阻遏Wnt (一种复杂的蛋白质作用网络,与毛发再生和伤口愈合有关) 信号通路,从而影响毛囊生长及再生秩序。
A new biomaterial developed by the team interferes with this binding process. It's called PTD-DBM, and when applied to the bare skin of bald mice for 28 days, new follicles developed.
为了干扰这种结合过程,研究人员研制出一种名为PTD-PBD的生物材料,并将这种物质涂在无毛白鼠皮肤上,持续28天后,白鼠长出了新的毛囊。
而根据2007年的一项研究,在小鼠实验中,某些情况下,直径超过5毫米的伤口在愈合时会产生新的毛囊。
The strongest result that Kang-yeol's team saw was after combining wound-induced hair neogenesis with PTD-PBM and valproic acid, usually used to treat seizures, bipolar, schizophrenia and migraines. In this instance it was used topically to activate the Wnt/β-catenin pathway.
崔康烈的研究团队发现,将创伤诱发毛发再生,PTD-PBD和丙戊酸结合起来,取得的效果最明显。丙戊酸通常用于治疗癫痫、双向情感障碍、精神分裂和偏头痛,在这个实验里用来激活Wnt信号通路。
So there's a threefold action. The wounds induce the generation of follicles; the valproic acid stimulates the cell pathway linked to the development of follicles; and the PTD-PBD inhibits prevents CXXC5 from interfering with the follicular development process.
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