"Thus, it is able to explain the correlation between the strength of the Warburg effect and tumour aggressiveness. This link between sugar and cancer has sweeping consequences. Our results provide a foundation for future research in this domain, which can now be performed with a much more precise and relevant focus."
“因此,我们找到了瓦博格效应与癌症的攻击性之间的关联。糖分和癌症之间的关系有着深远的影响。我们的研究成果为将来这一领域的研究提供了平台,今后的研究将具备更高的准确度,也更能分清主次。”
The team used yeast cells for its research – specifically looking at the 'Ras' gene family, a family of genes that is present in all animal cells, including human cancer cells. This makes the study of Ras mutations in yeast an increasingly useful tool in cancer research.
这支团队在研究中使用的是酵母细胞——特别采用了ras基因家族的细胞,这个基因家族存在于所有动物细胞中,特别是人类的癌症细胞。对酵母细胞中Ras变异的研究将越来越成为癌症研究的有力武器。
Yeast also has highly active sugar metabolism, yet doesn't have the additional regulatory processes of mammalian cells that can conceal underlying processes.
酵母细胞还具有高活性的糖分代谢功能,同时又不像哺乳动物细胞那样表现出附加的规范机制,这种规范机制会隐藏糖分代谢的过程。
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