这为艾滋病治疗方案的研发带来了新的挑战:相比于已得到广泛研究的、HIV潜伏在血液T细胞里的过程,病毒经由生殖器粘膜进入巨噬细胞的过程的发生时间要早得多。
"Once HIV is installed into a reservoir, it makes life very complicated if you want to eradicate the virus," Bomsel says.
邦塞尔称:“一旦病毒潜伏在免疫细胞中,想要根除就会让情况变得非常复杂。”
Treatment with antiretroviral therapies can keep reservoirs of the virus latent, but stopping the therapy allows the virus to rebound and continue spreading.
虽然使用抗逆转录病毒疗法可以使病毒保持潜伏状态,但是一旦停止这种疗法,病毒就会停止潜伏并继续传播。
"So an aim would be to act extremely early upon infection to avoid this reservoir formation, which is why I think a vaccine active at the mucosa is what you would need. Because you can't wait."
“因此,我建议在感染病毒的早期就采取措施来避免病毒进入这种潜伏状态,这也是为什么我认为在粘膜上发挥作用的疫苗才是患者真正需要的。因为我们不能等。”
This is something her team is already at work on. "We are trying to find ways to purge the reservoir, because we think we know how to kill the virus once we shock the reservoir. And another part of what we do here is work to develop a mucosal HIV vaccine," she says. "It's a complicated field, but I think it's important."
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