After an hour or two, once the virus has been produced and shed, the cell contact ends and the infected T cell moves on.
一两个小时后,一旦病毒产生和流出的过程结束,两个细胞的接触过程也结束,受感染的T细胞继续运动,寻找下一个感染对象。
These infected T cells are present in all genital fluids that vector infection. While cell-free viruses can cross the mucosa, they are much less efficient at penetrating it than cell-bound viruses that can make use of the virological synapse and transcytosis.
这些被感染的T细胞存在于所有类型的生殖器官感染中。虽然游离病毒可以在黏膜的细胞间隙中游走,但它们穿透粘膜的效率比细胞内的病毒低得多,后者可以利用病毒学突触和胞吞作用穿越整个粘膜上皮细胞层。
These macrophages continue to produce and shed the virus for 20 days, after which they enter a latent, non-virus-producing state. But the virus is still stored in the macrophage.
在接下来的20天里,这些巨噬细胞会继续产生并释放病毒,随后它们就进入了不产生病毒的潜伏状态,但病毒依然储存在这些巨噬细胞中。
This poses a challenge for efforts to develop treatments for HIV, because the virus reaches these macrophage reservoirs in the genital tissue much earlier in the infection process than more frequently studied T cell reservoirs in the blood.
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