Chinese scientists have identified a new protein that restricts HIV infection, a discovery that could pave the way for the development of new drugs against the virus. The protein, P-selectin glycoprotein ligand 1 (PSGL-1), which exists in human cells, can inhibit the process by which HIV replicates, according to research published in the science journal Nature Microbiology this month.
中国科学家新发现了一种可以抑制艾滋病病毒感染的蛋白质,这一发现或为研发抗艾滋病病毒的新药品开辟路径。本月于《自然·微生物学》科学杂志上发表的研究表明,P-选择素糖蛋白配体1(PSGL-1)蛋白质存在于人体细胞,可抑制艾滋病病毒的繁殖过程。
However, the study also showed that PSGL-1 can be negatively affected by Vpu-an accessory protein of HIV-which can neutralize the ability of PSGL-1 to resist HIV. Further research is underway to develop a drug that can inhibit the HIV protein so that PSGL-1 can restrict HIV, according to Tan Xu, a researcher at Tsinghua University's School of Pharmaceutical Sciences, a leading author of the study.
但是,该研究也表明PSGL-1会受到Vpu蛋白(艾滋病病毒的附属蛋白)的负面影响--Vpu会使PSGL-1无法抑制艾滋病病毒。清华大学药学院的研究员、本研究的主要作者谭旭(Tan Xu)表示,目前正开展进一步的研究以期研发一种可以抑制艾滋病病毒蛋白的药物,使PSGL-1抑制艾滋病病毒。
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