Several other proteins in human cells that could resist HIV have been discovered over the past 10 years, though the virus can also evade them. PSGL-1 shows particular promise in that it can inhibit the HIV in multiple ways-especially by blocking the infectiousness of virus offspring, Tan said.
过去十年来,研究员在人体细胞中发现了其它几种可抑制艾滋病病毒的蛋白质,但艾滋病病毒总能避开这些蛋白质。PSGL-1具有多重抗病毒功能,展现良好的前景--尤其能抑制新生病毒的感染,谭旭说道。
"We are starting to screen for small molecule compounds in the hope of finding one that can restore PSGL-1's anti-HIV function. In this way we can develop a very effective antiviral drug for people with HIV/AIDS," he said.
"我们正在筛选小分子化合物,以期找到能恢复PSGL-1抗艾滋病病毒功能的分子化合物。如此,我们可以开发一种非常有效的抗病毒药物用于治疗艾滋病病毒/艾滋病患者,"他说道。
Tan said it will require at least three to five years for the research to reach the preclinical stage, and more time after that before a clinical trial is possible. The research was conducted by researchers at Tsinghua University in Beijing, Fudan University in Shanghai and George Mason University in the United States.
谭旭表示,至少还需要再研究3-5年才能达到临床前阶段,在临床试验前,还需要更长时间。该研究由北京清华大学、上海复旦大学和美国乔治梅森大学的研究员合作展开。
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