The hunt is intensifying for new treatments for migraines, the common and debilitating headaches that have confounded scientists for decades.
人类正在加紧寻求治疗偏头痛的方法,这种让人身体虚弱的常见头痛病已经困扰了科学家数十年。
Of greatest focus for researchers is a brain chemical known as CGRP, which appears to play a role in the transmission of pain, but not in other brain functions, such as cognition or mood. Researchers are trying a variety of experimental drugs to stop CGRP from working by blocking its receptors in the brain. Others are working on artificial antibodies that could soak up the chemical in the bloodstream or brain before it can trigger migraines.
研究人员关注最多的是一种名为降钙素基因相关口(CGRP)的大脑化学物质,这种物质似乎与痛感传递有关,但是在认知或情绪等大脑的其它功能方面并没有造成影响。研究人员尝试使用各种实验药物,通过屏蔽大脑里感应CGRP的部分来阻止CGRP发生作用。还有一些人正致力于人工抗体的研制,使其在CGRP引发偏头痛之前将血液或大脑中的这种化学物质吸收。
Experts say the need for new medicines to treat migraine pain once it begins is great because current drugs only provide some benefit for 50% to 60% of sufferers and can't be used in people with heart disease or who have had a stroke. Also, they aren't a cure, and in many cases, the headaches tend to come back within 24 hours.
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