Chronic inflammation has been linked to heart disease, arthritis, Type 2 diabetes and even suicide attempts, Dr. Jaremka noted. People who are lonely also react more strongly to negative events and perceive daily life as being more stressful, which can depress the immune system.
雅雷姆卡博士指出,慢性炎症与心脏病、关节炎、II型糖尿病,甚至自杀企图有关。孤独的人在应对负面事态时,也易于做出更激烈的反应,并且认为日常生活压力重重,而这会抑制免疫系统。
Loneliness can even influence how genes are expressed, Dr. Cacioppo has found. Loneliness predicted changes in DNA transcription that in turn dampened the body’s ability to shut off the inflammatory response, he reported. A study by Dr. Carla M. Perissinotto and colleagues at the University of California, San Francisco, assessed loneliness among 1, 604 older adults and followed them for six years. Those who were lonely were more likely to develop difficulties performing activities of daily living like bathing and dressing, using their arms and shoulders, climbing stairs and walking. Loneliness was also associated with an increased risk of death during the study period.
卡奇奥波发现,孤独感甚至会影响基因表达。他指出,孤独感会预示DNA转录的变化,而这反过来会抑制机体关闭炎症反应的能力。加州大学旧金山分校(University of California, San Francisco)的卡拉·M·佩里西诺托(Carla M. Perissinotto)和同事们对1604名老年人的孤独感进行了评估,随访持续了六年。那些孤独的老人更有可能难以进行日常活动,比如洗澡和穿衣,使用胳膊和肩膀,爬楼梯和步行。在研究期间,孤独感与死亡危险上升也有联系。
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