The National Institute for Health and Care Excellence says growing numbers of people are injecting tanning agents, dermal fillers and Botox at home and in salons, and some are lax about hygiene.
Sharing needles can spread blood-borne diseases like HIV and hepatitis C.
Nice is updating its advice for England and Wales accordingly.
The guidelines, which are out for public consultation, aim to encourage people to use sterile needle and syringe programmes to stem the spread of infections.
Sharps bins
Most blood-borne diseases occur among people who inject drugs like heroin and anabolic steroids.
But NICE says people seeking out cosmetic fixes are also at risk.
A spokeswoman said: "We are seeing an increasing issue with drugs that are used for vanity purposes."
This includes the anti-wrinkle treatment Botox, dermal fillers and tanning agents.
Prof Mike Kelly, Director of the NICE Centre for Public Health Excellence, said: "Since we last published our guidance on needle and syringe programmes in 2009, we've seen an increase in the use of performance-and-image-enhancing drugs such as anabolic steroids, Botox, tanning agents and the use of dermal fillers like collagen.
"We've also heard anecdotal evidence that more teenagers are injecting these performance-and-image-enhancing drugs too.
"We're updating our guidance - and our public consultation on the draft update is an important part of this process - to make sure all of these groups of people are considered in the planning and delivery of needle and syringe programmes."
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