新的研究识别出了一种名为约氏乳酸杆菌(Lactobacillus johnsonii)的细菌,其与防止过敏反应存在很强的关联。林奇说,从一组老鼠的肠道中分离出这种细菌并植入另外的老鼠肠道后,被植入细菌的老鼠就获得了过敏保护。这些动物身上的免疫反应极大地降低了,它们看起来更为健康。
But they weren't as well-protected as mice with a more-diversified microbiome, suggesting other such organisms in the microbiome affect immune response.
但它们受到保护的程度不如有着更多样化菌群的老鼠,这表明菌群中还有其他类似生物影响着免疫反应。
Dr. Lynch and her colleagues, including researchers at the University of Michigan; the Henry Ford Health System, Detroit; and the Georgia Regents University, Augusta, are shifting the research to people. The aim is to develop probiotics or 'microbial based therapies' that might be used to prevent or treat asthma and allergies, Dr. Lynch said.
林奇与密歇根大学(University of Michigan)、底特律亨利・福特卫生系统(Henry Ford Health System)以及奥古斯塔Georgia Regents University的研究人员正将这项研究转向人体。林奇说,研究的目标是开发出基于益生菌或微生物的疗法,可能用于防止或治疗哮喘和过敏。
The study was funded by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.
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